"Highly sensitive, non-invasive, low-cost" colloidal gold method for screening Hp

Helicobacter pylori (Hp) infects about 50% of the world's population, with higher infection rates in developing countries. The bacterium is classified as a Class I carcinogen by the World Health Organization, and is associated with non-cardia gastric cancer at a rate of 78.5%. The risk of gastric cancer in infected people is 3-6 times that of uninfected people.

 

Susceptible population and health hazards‌

‌Infection

About half of the world's population carries Hp, and the infection rate in some areas exceeds 60%.

Susceptible population

Groups with a high risk of family cluster infections; residents in economically underdeveloped areas.

Health hazards‌

Short-term: Causes chronic gastritis and peptic ulcer;

‌Long term‌: Causes gastric mucosal atrophy and intestinal metaplasia, significantly increasing the risk of gastric cancer.

 

‌Transmission route‌

‌Mouth-to-mouth transmission‌: spread through shared tableware, saliva contact, etc.;

‌Fecal-oral transmission‌: contamination of food or water sources that are not thoroughly cleaned‌.

 

‌Comparison of detection technologies and core advantages of colloidal gold method‌

 

‌Detection method	Detection speed	‌Operation Difficulty	Cost	Applicable scenarios
‌Urea breath test (UBT)	20-30 minutes	Requires professional equipment and operation	Medium	Laboratories, Hospitals
‌ELISA (antibody test)	2-4 hours	Laboratory environment required	High	Large-scale screening
Rapid urease test (RUT)	30 minutes	Gastroscopy is required	Medium	Invasive diagnosis
‌Colloidal gold method (antigen/antibody)	‌10-15 minutes	No equipment required, non-professional operation possible	‌Very low	Primary care, family self-examination

‌ ‌ ‌ ‌ ‌

‌

‌Core advantages of colloidal gold method‌:

‌Sensitivity and specificity‌: Sensitivity>95%, using double antigen sandwich design to reduce cross-reaction;

‌Fast and convenient‌: Tests can be completed within 15 minutes and support serum, plasma or fecal samples;

‌Low cost‌: The cost of a single test is low, suitable for resource-poor areas;

No laboratory required: Store at room temperature and read results visually via color bands.

 

Galenus Medical has developed a Helicobacter pylori antibody rapid detection kit and a Helicobacter pylori antigen rapid detection kit for Helicobacter pylori detection. Both kits can be used for: early screening, by detecting stool antigens or serum antibodies to achieve early diagnosis of infection; primary medical care, replacing complex detection technologies under non-laboratory conditions to reduce the missed detection rate; home self-testing, providing high-risk groups with convenient self-testing solutions and shortening the diagnosis cycle.